Although letters of intent are not required, NIH advises to submit one If your chosen funding opportunity announcement (FOA) or notice of special interest (NOSI) requests one. Reviewers won’t see your letter of intent, so it won’t affect how they score your application.
Whether you submit a letter of intent or not, at least twelve weeks before you apply, it is recommended that you contact the NIH scientific program officials listed for your FOA or in your area of scientific research. They can advise on your application, point out special requirements that are important to the success of your submission and mention any prior approvals needed.
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